Comment on Mandates vs. Religious Exemptions by Sean Pitman.
What I’m saying is that this research isn’t relevant to real life when it comes to the actual risk of the mRNA vaccines turning themselves into DNA and then integrating themselves into the human genome. That simply isn’t a valid concern for several rather obvious reasons.
First off, you have to understand how this research was done. They took hepatic cancer cells, not normal human cells, and exposed these highly atypical mutated cells to large amounts of Pfizer’s mRNA vaccine in vitro. Then, they detected that the mRNA sequences had been decoded and that spike proteins were being produced – as expected. No surprise here. Then, they demonstrated that some DNA copies had been made of the mRNA via the reverse transcriptase in the cancer cells – knowing that cancer cells often produced increased quantities of reverse transcriptase. That’s it. That’s all that they demonstrated. But how is this relevant to real life? – to any kind of real risk for the mRNA vaccines? I’m not making this up. What the authors did was to deliberately set up an experiment with a highly mutated cancer cell line that they knew, ahead of time, would produce an outcome that doesn’t reflect what happens in real life with normal human tissues.
“Huh-7 is an immortal cell line composed of epithelial-like, tumorigenic cells. The majority of Huh-7 cells show a chromosome number between 55 and 63 (mode 60) and are highly heterogeneous… The cell model that we used in this study is a carcinoma cell line, with active DNA replication which differs from non-dividing somatic cells.”
Note that “Huh7 cells” specifically show “changes in gene expression of long interspersed nuclear element-1 (LINE-1)” – which is an endogenous reverse transcriptase. LINE-1 retrotransposons are necessarily active during embryogenesis are aberrantly active in tumorigenesis. cancer cell genomes substantially overexpress L1 (Link). L1 expression is directly related to the cell’s DNA damage response (Link). L1 levels are even being proposed as a biomarker to cancer screening (Link).
This is why these authors used these particular hepatic tumor cells. However, that is not enough, as reverse transcriptase does not integrate the DNA strands thus produced into the human genome. A second enzyme is needed – an integrase. Integrases insert the double-stranded DNA produced by reverse transcriptase into the host’s chromosomal DNA. And, this particular step was not demonstrated in this study since the required integrase enzyme wasn’t shown to be produced by these hepatic cancer cells (since integrase is produced by retroviruses, not human cells).
Clearly, then, what the authors of this paper did not demonstrate is that there is a real risk of any kind for actual humans in real life. In short, there is no significant risk of getting the mRNA vaccines to alter the human genome – given that the mRNA vaccines are injected into the deltoid muscle and locally taken up by these muscle cells, not cancer cells. These muscle cells, unlike the hepatocellular cancer cells, have no significant levels of reverse transcriptase or integrase production.
This is basically the same thing as with the last article you cited with concerns over the mRNA vaccines altering the human genome. Such concerns simply aren’t based on the weight of reasonable scientific evidence, which is abundant.
See also the interesting commentary about this by David H. Gorski, MD, PhD: Link
Sean Pitman Also Commented
Mandates vs. Religious Exemptions
I’m just saying is that if you think that what you say on blog sites like this one doesn’t really affect people, especially when you present yourself as an MD, you’re mistaken. I know that people have been influenced against taking the mRNA vaccines by what you’ve said here in this forum. You’re not simply being neutral in what you’ve posted. You do, in fact, come across as being opposed to the mRNA vaccines – also noting that you didn’t get vaccinated yourself and chose to get infected by the live COVID-19 virus without pre-established vaccine-based immunity. You’ve also come across as being strongly against any response by me to the articles that you’ve referenced where I point out how these papers really do not actually undermine the efficacy and/or the relative safety of the mRNA vaccines. Clearly, you don’t come across as being neutral on the topic.
And, such comments have an effect on people – they really do. While that upsets me, again, it’s more important to me to allow for those who disagree with me to also post their comments rather than to only allow what I personally think is true to be posted.
Beyond this, no one is twisting your arm to post our comments here. You can post or not post as you wish. That’s entirely up to you. But, don’t expect that I won’t push back when you post comments that I think will increase the risk of those who read what you have to say…
Mandates vs. Religious Exemptions
The difference between us is that I see people in the ICU, as does my brother-in-law Dr. Roger Seheult (a pulmonologist in S. Cal.). You might see the occasional person die from COVID-19, but those who work ICUs in larger medical centers see far too many people die from COVID-19 – to include young people (not just those in nursing homes). You might offer the vaccine to those whom you see, but if you present arguments to them like the ones you’ve presented here, such advice most certainly does result in increased injuries and even death. For me, that’s a big deal. You might call it “weird and overly dramatic” if you want, but for me the effort to save lives and reduce injuries is neither “weird” nor “overly dramatic”. I mean, that’s why I do what I do…
Now, you say, “The discussions that I have on blogs like this are my personal thoughts and concerns. They don’t reflect the way that I actually practice primary care medicine on a daily basis.”
That would be great if this were a private conversation, but it isn’t. It is a public conversation and your words have an impact on the hundreds who read this blog every day. I mean, in a very real sense, especially given that you include your title “MD” with your name, and often point out that you are a medical doctor when you post to this blog, you are, in fact, practicing medicine when you post public comments like you do. You cannot simply say, “I don’t actually follow my own advice that I post in blogs when I practice primary care medicine on a daily basis.” Your influence simply isn’t limited to what you do face-to-face with patients in your clinic. Your influence also extends to what you say and do in front of people outside of your daily medical practice.
Mandates vs. Religious Exemptions
Well, I’m glad you go at least this far… although I still think that the kinds of arguments you present here really do put people’s lives and health at increased risk. I know you don’t agree, but that’s how I see things from my own perspective.
Now, I’m fine with you, and those who think like you, having the ability to freely share your opinions – despite how mistaken and damaging I personally think these opinions may be. That’s just the nature of living in a free society – which I think is far more important than restricting the freedom of speech.
Recent Comments by Sean Pitman
Natural vs. Vaccine-derived Immunity
Toby Rogers is a political economist who is also strongly anti-vax. He is not a medical scientist or physician.
In any case, this particular article, by Rogers, distorts the data regarding vaccines and the position of Dr. Peter Aaby – who is a strong supporter of vaccines in general (although, when it comes to COVID-19 vaccines, he seems to favor the adenovirus-based vaccines, such as Johnson and Johnson, AstraZeneca/Oxford or the one produced by China’s CanSino Biologics, over the mRNA-based vaccines – since the adenovirus-based vaccines may have more benefit on reducing “overall mortality – Link). Note, however, that this study found that of the 31 deaths that occured in mRNA-vaccinated individuals, only two were from COVID-19. The rest were due to other causes. For the adenovirus-vaccinated group, two of the 16 deaths were from COVID-19. It’s very difficult, then, to determine a clear relationship here between the different types of vaccines and deaths not related to COVID-19.
“The study isn’t about the effectiveness of mRNA vaccines against COVID,” said Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health and Security. “The study is aimed to determine if COVID vaccines have non-specific mortality impacts that extend beyond the incontrovertible mortality benefit they confer with COVID-19. Certain vaccines have effects that extend beyond the target infection and decrease mortality from other causes (e.g. measles vaccine).”
Dr. Monica Gandhi, an infectious disease specialist at the University of California, San Francisco, also said the question of the paper isn’t about COVID-19, but whether the vaccines had a beneficial effect on other causes of mortality. The research reinforced that both types of vaccines significantly prevented COVID-19 deaths, “which is not surprising as both types of vaccines generate cellular immunity against SARS-CoV-2, protecting us against severe disease.”
“However, to be fair,” Gandhi said, “the number of non-COVID and COVID deaths were rare in all of the pooled analyses and the causes of non-COVID deaths not well adjudicated, so this analysis needs to be taken as preliminary and hypothesis generating at best.”
What’s interesting here is that studies have shown that the “all cause” mortality rate is also reduced for those who have been vaccinated against COVID-19 – to include those who’ve been vaccinated via the mRNA-based vaccines (Link).
Anyway, here’s a more balanced view of Dr. Aaby’s position on vaccines (Link). Note also that Dr. Aaby supported the vaccines against COVID-19 for adults (Link), but not necessarily for children since children have significantly reduced risk (compared to adults) for COVID-19 infections (Link). Dr. Aaby did publish some interesting results, however, suggesting that the polio vaccine, as well as the BCG and MMR vaccines, may also reduce childhood risk from COVID-19 as well (Link, Link).
“We would not be surprised if MMR could provide some protection against severe COVID-19,” said researcher Peter Aaby, of Bandim Health Project in Guinea-Bissau and Research Centre for Vitamins and Vaccines (CVIVA), Statens Serum Institut, a governmental public health and research institution under the Danish Ministry of Health in Copenhagen, Denmark and a pioneer in the field. “Together with my partner Dr. Christine Stabell Benn, we’ve been reporting on mortality reductions from live-attenuated vaccines such as polio, BCG and measles vaccine/MMR for multiple decades now, and arguing for optimized vaccine schedules. With the COVID-19 crisis adding urgency, it’s good to see the potential of non-specific immune effects being taken seriously.” (Link)
Overall, I do find Dr. Aaby’s main concern to be well-supported that vaccines may produce unforseen beneficial as well as detrimental side effects. In the case of COVID-19, however, it was very clear to me that the potential unknown risks were clearly outweighed when compared to the known risks of getting infected by COVID-19 as well as the very clear known benefits of being vaccinated – particularly for adults over the age of 50 and those with various medical conditions that put them at great risk. Even healthy children seemed to be far more at risk from a live COVID-19 infection than from the vaccines – particularly regarding long-term effects. Of course, this was all before the current less severe Omicron variant took over and the predominant variant worldwide. At this current point in time, vaccines against COVID-19 don’t seem to me to have as significant of an advantage compared to earlier on in the pandemic.
Hope this helps,
Back to Square One…
I’m not sure what “teachings” you have in mind here that need amending?
What we believe
The book “Genetic Entropy” wasn’t written by me, but by John Sanford (who isn’t SDA by the way).
I’m glad that you found a saving relationship with God – salvation by faith in God’s grace. While I’m sorry that you didn’t find this in whatever SDA Church you were once a part of, it is, in fact, fundamental teaching of the SDA Church, as an organization, and is also strongly promoted in the writings of Ellen White. The “Investigative Judgment”, by the way, is a very good thing because, according to the Bible itself, judgment is given “in favor of the saints” (Daniel 7:22) – all of whom are saved by faith and by God’s Amazing Grace.
Anyway, it seems to me as though you have the wrong impression about what the Seventh-day Adventist Church is all about. We are all about salvation by faith in God’s Amazing unmerited Grace alone…
BCC revealed that they use “a little bit of AIDS” in vaccine.
That’s not true at all. The initial concern back in 2020 was that the Adenovirus vector-type vaccines, particularly those that used an adenovirus type 5 (Ad5) vector, (not the mRNA vaccines or other viral vector vaccines) might produce an increased susceptibility in gay or otherwise promiscuous men to HIV infection (Link, Link, Link). This isn’t because there is HIV within this particular type of vaccine. Rather, the concern was that this particular “type 5” adenovirus-based vaccine would enhance the ability of the HIV virus to infect men who were living a risky lifestyle with respect to HIV exposure – due to a form of “antibody-dependent enhancement” or “ADE”.
In this light, note that the Chinese CanSino COVID-19 vaccine uses the Ad5 vector, and the Russian Sputnik V vaccine uses both Ad5 and Ad26 vectors. However, the Johnson & Johnson vaccine uses Ad26 only. The AstraZeneca-Oxford COVID-19 vaccine uses a chimpanzee adenovirus. None of these types of viral vectors have been associated with the ADE problem that is known for the Ad5 vector with respect to enhanced HIV infectivity. Of course, the Pfizer-BioNTech and Moderna messenger RNA (mRNA) vaccines do not use adenovirus vectors at all, so clearly these don’t have this ADE problem either.
Now, given the concerns for vaccines based on the Ad5 vector, in particular, authorities in South Africa—where HIV incidence is high declined to authorize the Sputnik V vaccine, and Namibia suspended its use (back in October of 2021: Link).
In short, this isn’t a concern for the mRNA vaccines or any other COVID-19 vaccine used in the United States and Europe – and it isn’t a concern for those who are not exposing themselves to an increased risk for HIV infection (such as living a sexually promiscuous lifestyle).
Pastor Doug Hardt: Vaccines, Liberty and the Bible
A term promoted by Dr. Robert Malone? – borrowed from Mattias Desmet? – attempting to make parallels with Nazi Germany and the rise of Hitler in the 1930s? where millions of people have been “hypnotized” into believing mainstream ideas about COVID-19, including steps to combat it such as testing and vaccination? Yes, I’ve heard of it. What nonsense (Link).
Just because you’re swimming against the crowd, just because you’re in the minority, doesn’t mean that you’re right. Occasionally, the consensus opinion of medical scientists, experts in their fields of study, who have devoted their lives to studying such things as pandemics and vaccines, is actually right.