I’m not a fan of censorship (at least not within …

Comment on Review of “The Surge” with Dr. Lela Lewis and Friends by Sean Pitman.

I’m not a fan of censorship (at least not within reason). However, public media platforms, in this country, are free to make their own rules regarding what ideas they want or do not want to offer their platform as a means of broadcast. I might not agree with their decisions, but that’s their free choice.

As far as ivermectin is concerned, I’ve had many people send me this very same meta-analysis paper that you reference, along with the argument that it works “if given early enough” following infection. The problem with these “meta-analysis” studies is that putting together an analysis on a bunch of small studies that individually have limited predictive power doesn’t necessarily make the overall meta-analysis any better than the largest and most statistically significant single underlying study. As Gorski and others point out, meta-analyses are only as good as their raw material – a phenomenon Gorski labels “garbage in, garbage out.” That’s the reason why larger double-blinded placebo-controlled trials are seen as more reliable, generally speaking, compared to meta-analysis papers. The problem here is that the preliminary results from such a trial, known as the “Together Trial” (consisting of nearly 2300 participants in a Phase 3 randomized, double-blind, placebo-controlled trial), showed no significant effect on reducing emergency room visits or hospitalizations – despite “early treatment”.

Another smaller double-blinded randomized placebo-controlled trial, involving 476 patients, also failed to show any advantage for ivermectin use (Lopez-Medina, March 4, 2021).

Now, you suggest that this lack of evidence from this trial might be due to some sort of bias in these trials. Perhaps, but I don’t see how this is likely. This is especially true given that this particular meta-analysis paper that you reference (by Dr. Pierre Kory, et. al.) was published April 22, 2021. Why might this be a problem? Because, it was published before the paper published by Dr. Ahmed Elgazzar from Benha University in Egypt, was withdrawn because it was shown to be fraudulent (originally published on the Research Square website in November, 2020) (Link). Dr. Kory’s meta-analysis paper depends heavily upon the Elgazzar paper – which is now known to be completely worthless. If one removes the Egypt data and re-runs the meta-analysis, “the benefit…largely loses its statistical significance.” (Link)

Now, I really wish there were clear evidence that ivermectin and/or hydroxychloroquine worked, but so far, I just don’t see the claims in this regard as being supported by the weight of evidence that is currently in hand.

Do I think Dr. Kory was lying? No. I think he really believed in and probably still believes in ivermectin as a useful treatment for COVID-19. I just think that various treatment protocols, that I think have shown some good success, which are attributed to ivermectin or hydroxychloroquine, are far more likely the result of some of the other drugs being used – such as steroids, monoclonal antibodies, etc…

As far as your understanding of natural immunity, it’s actually the opposite of what you imagine. Sure, while natural immunity derived by a full-blown infection by COVID-19 will produce a broader spectrum of antibodies and T-cells, this doesn’t mean that such immunity will be better at fighting off a COVID-19 infection or subsequent variants of the original virus. The reason for this is that natural immunity is, in fact, so broad-spectrum that it doesn’t produce the concentration of targeted antibodies that vaccine-based immunity produces, against a small target. It is precisely because the target for vaccine-based immunity is so much smaller than the many targets for naturally-acquired immunity, that the vaccine-based immunity is, in fact, better able to stop mutational variants – since the sequence space open to variations of a small target region is much smaller (without a complete loss of function for that target sequence). There is, however, an advantage to naturally acquired immunity. If someone with naturally acquired immunity get vaccinated with an mRNA vaccine, the resulting immunity, for that person, will generally be better than someone who only has vaccine-based immunity (as explained in more detail in my article above).

As far as the argument that “natural immunity lasts – usually for a lifetime” that’s sometimes true and sometimes not true – depending upon the type of infection that produced the natural immunity. The big advantage of vaccine-based immunity is, of course, gaining useful immunity without the body having to go through a potentially lethal or debilitating infection first. You reference “tested vaccines” like polio and smallpox vaccines, but many other “tested vaccines” require boosters. Again, it all depends. And, it’s not like the mRNA vaccines haven’t been “tested”. They have been extensively tested via double-blinded placebo-controlled trials in both humans and animals. And, even before these tests, they have been around and have been carefully studied and used for over 30 years.

Sean Pitman Also Commented

Review of “The Surge” with Dr. Lela Lewis and Friends
The dosage doesn’t matter much within this range (and the TOGETHER Trial used a dose of 400 μg/kg/day). There is also no evidence for “synergism” between ivermectin and other drugs used in McCullough’s early-treatment protocol (or other such protocols such as the MATH+, I-MASK+ and I-RECOVER Protocols) – despite him making this very same argument (Link).

The problem, as mentioned in my article, “You can’t just throw together drugs that don’t work at all by themselves and expect that they will suddenly work if used in combination – Dr. Vincent Iannelli explains (Link). There just is no scientific evidence or any kind of mechanism for this when it comes to efforts to save ivermectin as providing some kind of benefit against COVID-19.

See also a recent review of the Cochrane Review of ivermectin: Link


Review of “The Surge” with Dr. Lela Lewis and Friends
Yes, I generally agree with Dr. Damania (Dr Zdogg) and have watched many of his videos. He’s a good place to start researching a topic if he has actually made a video about it.


Review of “The Surge” with Dr. Lela Lewis and Friends
Actually, since the Egyptian data comprised so much of the basis for Dr. Kory’s meta-analysis paper, removing this data from his analysis actually removes the useful predictive value of his analysis beyond random chance – as previously explained.


Recent Comments by Sean Pitman

Natural Immunity vs. Vaccines vs. the Delta Variant

I’m glad you reached the conclusion that the immune system God designed into our bodies gives better protection against infection than vaccines do.

God didn’t “design” COVID-19 derived immunity any more than vaccine-derived immunity. What God designed was an immune system that could learn from past infections (or exposure to foreign antigens) in order to prevent future infections by the same type of invader more effectively.

You see, I’m not sure that we have the same definition of “natural immunity” in the context of COVID-19 here. The human body was designed with two different types of immune systems known as the “innate” and “adaptive” immune systems. Consider, now, that I’m not talking about generalized immunity that isn’t specific or targeted against COVID-19 in particular. In other words, I’m not talking about the “innate” immune system. What I am talking about is the “adaptive” immune system – a type of immunity that can be gained by surviving a “natural infection” to COVID-19 – which then produces “natural immunity” or “naturally-derived immunity” within the adaptive immune system that is specifically targeted against future COVID-19 infections. And, as already mentioned, while this “natural” method of gaining targeted adaptive immunity can be superior to the immunity gained by vaccines, for some people, it is far riskier and is not nearly as consistent as vaccine-derived adaptive immunity.

But, you counter with the argument that vaccines are also not consistent since there are “breakthrough infections”. However, the consistency I’m talking about is in regard to the reduction of and deaths – not just breakthrough nasopharyngeal infections (which aren’t the real problem). As noted in my McCullough article (Link), a fairly new study showed that the “percentage of variant cross-binding memory B cells was higher in vaccinees than individuals who recovered from mild COVID-19.” (Goel, et al., August 23, 2021). In this regard, it seems as though those who were vaccinated have an advantage in that the resulting immunity is more consistent and predictable as compared to natural immunity. These higher levels of memory B-cells within vaccinated people may also be the reason for the long-term protection against hospitalizations and deaths – despite the waining levels of antibody levels against the virus over time. Memory T- and B-cells produced in response to the vaccine can be “awakened” when an infection hits the body, a pre-formed arm that is ready to fight off the repeat offender.

There is also the problem that up to a third of people who were previously infected by COVID-19 don’t develop antibodies against it (Liu et al., September 2021). Ultimately, 36% of those who were infected by COVID-19 remained seronegative, meaning that they never developed detectable levels of such antibodies in their blood, even when multiple blood samples were checked for each person. The study also revealed that people who had lower SARS-CoV-2 viral loads in their respiratory tract were less like to subsequently have antibodies in their blood. This means, of course, that the adaptive immune system was never educated enough to effectively combat future infections by COVID-19.

So, you see, the vaccine may not reach as high a level of immunity as is gained by some who survived a prior infection by COVID-19. However, the level of immunity gained, when it comes to reducing hospitalizations and death, is more consistent for the vaccinated. This is the reason why there are so many stories of those who thought that they were safe, because of some previous mild COVID-19 infection, but then got infected again with COVID-19 and got very sick, particularly with the Delta Variant, with many dying as a result.

As far as your “alternative views” being more hopeful and less scary, that would be the case if they were actually true. The problem is that the conspiracy theorists that you consistently follow paint the vaccines as much more risky and scary than they truly are and the COVID-19 pandemic as much less serious and much less scary than it really is. They also create far more confidence in alternative drugs and therapies, like ivermectin for instance, than is actually supported by the weight of scientific evidence. That’s the problem. They create fear where there shouldn’t be fear and they create confidence where there shouldn’t be so much confidence. They get things exactly backward.

This is not to say that I think things were handled by the government very well at all. I don’t think it was necessary to shut down the government, for one thing. However, this is all 20/20 hindsight of course.

As far as the “miraculous recoveries” you mention, these are far too few. There are far far too many hospitalizations, serious long-term injuries, and deaths to be very comforted by miraculous recoveries. Clearly, these miraculous recoveries aren’t remotely common enough nor are they associated with drugs like ivermectin or hydroxychloroquine which have, so far, not shown a consistently detectable benefit in the best and largest RCTs.

Sure, ivermectin has relatively few side effects (unless you overdose) and a low mortality rate. However, it’s not as though the mortality risk is zero. “Between the years 2003 and 2017, the total average population treated [with Ivermectin] was around 15,552,588 among which 945 cases of SAE [severe adverse effects] were registered in DR Congo, i.e. 6 cases of SAE for 100,000 persons treated per year. 55 deaths related to post-CDTI SAE were recorded, which represents 5.8% of all cases of SAE.” (Link). Still, the point here is that even if the risks for ivermectin were actually zero, there’s still no good evidence that it provides much of a useful benefit – certainly nothing close to the benefits provided by the vaccines against COVID-19.

Yet, you write:

If an alternative drug is safer than aspirin and there are thousands of claimed recoveries resulting from the drug, isn’t it worth a trial, no matter what the “studies” say, considering the alternative is often death after being on a ventilator?

It might be worth a try if that was your only option. However, it isn’t your only option. Now that we have vaccines that provide a very clear and very substantial benefit, it is far far more reasonable to take the vaccines than to trust that ivermectin will save you – when the best scientific studies have yet to detect much of a benefit, even with early treatment, at reducing severe COVID-19 infections or death.

But it’s okay. We each can choose a path that is consistent with the best evidence as we understand it. For that matter, it seems to me that vaccination is the best course for many but not for others. Most don’t bother to understand just what these COVID vaccines do, much less do a benefit-risk analysis. But some of us do, and some of us find that avoiding the COVID vaccine, boosting our immune system and preparing for a possible infection is the best path for us.

You’re certainly free to choose. However, your choice could impact others – in a negative way. If the vaccines really do significantly reduce the odds of transmitting the virus to others (as several studies have shown), the choice of a person not to get vaccinated increases the odds of viral transmission to others who might not do as well against a COVID-19 infection. We aren’t islands here. Our choices have the potential to affect other people.

But, you think you can “boost your immune system” some other way. I wish this were true, but there just isn’t any other way that is as effective as the vaccines at the moment. The problem is that as humans age, our immune systems deteriorate at an almost exponential rate. Diet and healthful living do help, to be sure, but this does not negate the need to take advantage of the additional substantial advantages offered by vaccines – and this becomes more and more true the older and older we get. Add as many layers of protection as you can. Do it all. Be as healthy as you can be – AND take the vaccine.

Consider also that even a very healthy young person, who personally might have a very low risk of serious sickness or death, can still get infected and transmit the virus to others who might not do so well with an infection.

I suspect everyone will be exposed to this corona virus sooner or later, just as we have been to other corona viruses.

Indeed. However, the faster we can achieve herd immunity, as a community, the more those who are most vulnerable among us will be protected. And, the fastest and safest way to do this is via vaccines.

What concerns me most is the lack of respect among Christians for those with opposing views. While I don’t see vaccination as a salvation matter, an attitude of forcing others into agreement with our views is not an attitude born of the Spirit of God but of the enemy. I believe we can agree on that.

Love and respect never go out of style. However, there are times when the most loving thing to do is to protect those who are most vulnerable from those who are unwilling to act in a way that best protects the most vulnerable – particularly, say, in a hospital or nursing home setting. This isn’t to say that I’m a fan of government mandates for the general population. I’m not. I think that such mandates are largely counterproductive. Given that the vaccines are generally available for those who want them now, it seems best to me to limit mandates to those who work in settings where people are sick or old or otherwise vulnerable.


Natural Immunity vs. Vaccines vs. the Delta Variant
You’re commenting on an older post regarding natural immunity. Since then, additional evidence has indeed come to light showing that natural immunity goes well beyond antibody production and is therefore generally superior to vaccine-based immunity. Of course, vaccine-based immunity does have a couple of advantages over natural immunity. The most obvious advantage, of course, is that vaccine-based immunity is gained without having to take on the significant risks associated with getting infected by COVID-19. The additional advantage of vaccine-based immunity is that it seems to offer more consistent immunity compared to natural immunity (i.e., some who were infected don’t gain significant immunity following infection).

I discuss all of this in much more detail here: Link

As far as being more critical of evolutionists, look, I’ve reviewed a great many conspiracy claims. I usually get several sent to me every day. It’s not like I haven’t reviewed these claims you’re sending my way. It’s just that they almost always turn out to be completely false or misleading. It’s the same thing as with the evolutionary arguments I get – except it’s now on the other foot. What you believe regarding COVID-19 and vaccines simply doesn’t have the weight of empirical evidence to back it up. I know the claims of conspiracy theorists can be scary and worrisome. However, that doesn’t mean that they’re true. They just aren’t true. The minority opinion isn’t always true. In fact, the majority of experts are usually right – as in this case.


COVID Vaccine Myths, Questions, and Rumors with Drs. Rhonda Patrick and Roger Seheult
There are always rogue doctors around selling snake oil remedies and forwarding a host of conspiracy theories. That doesn’t mean that there isn’t a strong consensus in the medical community regarding COVID-19 and the efficacy and relative safety of the vaccines. A handful of doctors spreading conspiracy theories shouldn’t overcome one’s ability to see that the significant weight of empirical scientific evidence strongly supports the consensus conclusion in this case. After all, over 98% of medical doctors in this country are now vaccinated – particularly those working in ICUs who see that the unvaccinated are by far more likely to end up in the ICU and die with COVID compared to the vaccinated – by a ratio of more than 10:1 for any given age category.


COVID Vaccine Myths, Questions, and Rumors with Drs. Rhonda Patrick and Roger Seheult
While I agree, part of the problem is that people, in general in this country, simply don’t want to live healthful lives despite actually knowing that what they are doing isn’t healthy or good for them. When I was doing primary care, this was a constant frustration. You could tell people all day long what they should be doing, and they would usually even agree, but they just wouldn’t actually do what they knew they should be doing…


COVID Vaccine Myths, Questions, and Rumors with Drs. Rhonda Patrick and Roger Seheult
Sure, it’s very unfortunate that this pandemic has been so politicized. However, just because we know the final outcome doesn’t mean that this is it. We shouldn’t bring on the “Time of Trouble” before it’s actually here. During this particular pandemic we, particularly as Christians, should strive to separate medical science from politics. Merging them will only cause more harm. Many people really are suffering and dying due to COVID-19 and the mRNA vaccines have proven themselves to be very effective at preventing serious sickness and death.