Toby Rogers is a political economist who is also strongly …

Comment on Natural vs. Vaccine-derived Immunity by Sean Pitman.

Toby Rogers is a political economist who is also strongly anti-vax. He is not a medical scientist or physician.

In any case, this particular article, by Rogers, distorts the data regarding vaccines and the position of Dr. Peter Aaby – who is a strong supporter of vaccines in general (although, when it comes to COVID-19 vaccines, he seems to favor the adenovirus-based vaccines, such as Johnson and Johnson, AstraZeneca/Oxford or the one produced by China’s CanSino Biologics, over the mRNA-based vaccines – since the adenovirus-based vaccines may have more benefit on reducing “overall mortality – Link). Note, however, that this study found that of the 31 deaths that occured in mRNA-vaccinated individuals, only two were from COVID-19. The rest were due to other causes. For the adenovirus-vaccinated group, two of the 16 deaths were from COVID-19. It’s very difficult, then, to determine a clear relationship here between the different types of vaccines and deaths not related to COVID-19.

“The study isn’t about the effectiveness of mRNA vaccines against COVID,” said Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health and Security. “The study is aimed to determine if COVID vaccines have non-specific mortality impacts that extend beyond the incontrovertible mortality benefit they confer with COVID-19. Certain vaccines have effects that extend beyond the target infection and decrease mortality from other causes (e.g. measles vaccine).”

Dr. Monica Gandhi, an infectious disease specialist at the University of California, San Francisco, also said the question of the paper isn’t about COVID-19, but whether the vaccines had a beneficial effect on other causes of mortality. The research reinforced that both types of vaccines significantly prevented COVID-19 deaths, “which is not surprising as both types of vaccines generate cellular immunity against SARS-CoV-2, protecting us against severe disease.”

“However, to be fair,” Gandhi said, “the number of non-COVID and COVID deaths were rare in all of the pooled analyses and the causes of non-COVID deaths not well adjudicated, so this analysis needs to be taken as preliminary and hypothesis generating at best.”

(Link)

What’s interesting here is that studies have shown that the “all cause” mortality rate is also reduced for those who have been vaccinated against COVID-19 – to include those who’ve been vaccinated via the mRNA-based vaccines (Link).

Anyway, here’s a more balanced view of Dr. Aaby’s position on vaccines (Link). Note also that Dr. Aaby supported the vaccines against COVID-19 for adults (Link), but not necessarily for children since children have significantly reduced risk (compared to adults) for COVID-19 infections (Link). Dr. Aaby did publish some interesting results, however, suggesting that the polio vaccine, as well as the BCG and MMR vaccines, may also reduce childhood risk from COVID-19 as well (Link, Link).

“We would not be surprised if MMR could provide some protection against severe COVID-19,” said researcher Peter Aaby, of Bandim Health Project in Guinea-Bissau and Research Centre for Vitamins and Vaccines (CVIVA), Statens Serum Institut, a governmental public health and research institution under the Danish Ministry of Health in Copenhagen, Denmark and a pioneer in the field. “Together with my partner Dr. Christine Stabell Benn, we’ve been reporting on mortality reductions from live-attenuated vaccines such as polio, BCG and measles vaccine/MMR for multiple decades now, and arguing for optimized vaccine schedules. With the COVID-19 crisis adding urgency, it’s good to see the potential of non-specific immune effects being taken seriously.” (Link)

Overall, I do find Dr. Aaby’s main concern to be well-supported that vaccines may produce unforseen beneficial as well as detrimental side effects. In the case of COVID-19, however, it was very clear to me that the potential unknown risks were clearly outweighed when compared to the known risks of getting infected by COVID-19 as well as the very clear known benefits of being vaccinated – particularly for adults over the age of 50 and those with various medical conditions that put them at great risk. Even healthy children seemed to be far more at risk from a live COVID-19 infection than from the vaccines – particularly regarding long-term effects. Of course, this was all before the current less severe Omicron variant took over and the predominant variant worldwide. At this current point in time, vaccines against COVID-19 don’t seem to me to have as significant of an advantage compared to earlier on in the pandemic.

Hope this helps,

Sean

Sean Pitman Also Commented

Natural vs. Vaccine-derived Immunity
I’m biased here since I’m a physician myself. While I personally do not favor vaccine mandates for the general public since I think that they are largely counterproductive, I personally feel that medical providers are in a different category and that medical providers (like doctors and nurses and nursing home workers) should be required to be vaccinated since they deal directly with those who are sick and most vulnerable to serious infection. Timely boosters should also be required for medical personnel since boosters have clearly been shown to improve immunity after 6 months since the previous vaccine was given.

As far as “Long-COVID”, it is a real risk following a COVID-19 infection, but isn’t a risk following vaccination. The vaccines have not been associated with the symptoms of Long-COVID since vaccines are not based on the use of a live virus that invades the entire body. In fact, there are some research studies that suggest that many Long-COVID cases are likely related to persistent COVID-19 infections (Link). This is probably why many of those who have Long-COVID improve following vaccination.


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