Yes, that’s right. However, if it happens, and that’s …

Comment on Why Vaccinate Kids Against COVID-19? by Sean Pitman.

Yes, that’s right. However, if it happens, and that’s still a big if, it seems to be limited to very rare live viral infections – not in response to the mRNA vaccines as far as I can tell. One problem for the LINE1 method is that this method is almost always restricted to the nucleus of the cell. RNA in the cytoplasm of a cell also requires a “primer” sequence to initiate reverse transcription, usually in the form of small portion of DNA. When this rarely happens via an RNA sequence looping back on itself, cDNA is produced in the cytoplasm – which doesn’t enter the nucleus (Link). All of these problems pose significant challenges for the hypothesis that the LINE1 mechanism could integrate viral mRNA that doesn’t come with it’s own set of enzymes.

For this reason, the proposal of Zhang et. al., that this does rarely happen is not without controversy. A recently released bioRxiv preprint also suggested that the human SARS-CoV-2 chimeric transcripts detected through RNA sequencing may arise as a sample prep artifact rather than true reverse transcription, integration, and expression. Here’s a portion of an interesting discussion along these lines:

Ellen Foxman, MD, PhD, assistant professor in the department of laboratory medicine at Yale School of Medicine, reiterated the same concerns. “My overall take on this [PNAS] paper is that it is exploratory research, and that while the data suggests that fragments of the SARS-CoV-2 genome can become integrated in human cells, other explanations for the data are also possible, as the authors discussed.”

“Some critics contend that the physiological levels of reverse transcription machinery in human cells are very low and insufficient for cellular integration of SARs-CoV-2. In their cell line experiments, Jaenisch’s team transfected HEK293T cells with LINE1 prior to infection with SARS-CoV-2 to increase the likelihood of detecting rare integration events. This has prompted critics to question the biological relevance of the detected chimeric transcripts.”

Burgio said, “These integration events were found in a context of strong overexpression of LINE1 transposable elements, which is not seen in a real-life setting.”

“LINE1 expression is induced in cells under stress,” countered Jaenisch. “Stress can be induced by infection with a virus, by exposure cytokines, by aging, in cancer. So, you could argue when a patient is infected with [SARs-CoV-2] virus it induces LINE1 and that promotes integration… it is a very clear possibility.” The team presented evidence supporting the induction of LINE1 by virus infection. Analogous results have also been observed by other groups.

“There is no evidence presented that the extremely rare events proposed in this paper would be harmful to human health or could result in live SARS-CoV-2 viruses being produced,” said Foxman.

Jaenisch agreed and emphasized, “The biggest piece of [viral] DNA we find is 5% of the viral genome, 1,600 bps. There is absolutely no way in which infectious virus can be made from these integrated sequences.”

Genetic Engineering and Biotechnology News

Specifically regarding the mRNA vaccine producing this effect:

“There is absolutely no reason to believe that any of the vaccine mRNA is doing the same thing. The viral spike protein mRNA is a tiny piece. Vaccines are not inducing LINE element RTs,” said Young. “Vaccines are protecting against the possibility of long-term seriously debilitating diseases or death.” (Link)

Sean Pitman Also Commented

Why Vaccinate Kids Against COVID-19?
Assuming the 90% efficacy figure for the Pfizer vaccine holds up, vaccinating one million 5- to 12-year-old children would prevent 33,600 cases and 170 hospitalizations over 120 days. The CDC puts the figure about 58,000 cases and 226 hospitalizations prevented. During the same period of time, there would be around 21 cases of myocarditis or pericarditis (Link, Link). There is also the argument that the significant majority completely recover from vaccine-related myocarditis/pericarditis without any long-term effects. Recovering from a COVID-19 infection requiring hospitalization, however, often results in long-term injuries.


Why Vaccinate Kids Against COVID-19?
While vaccinating children is certainly more of a gray area as compared to vaccinating adults and those with pre-existing medical conditions, there are benefits to vaccinating children that Dr. Martin Kulldorff failed to mention – such as injuries that happen even if a child doesn’t die. These injuries and longer-term problems aren’t exactly rare either – as described in my article above. There is also the issue of children spreading the virus to others who are more susceptible.

Even death, while relatively uncommon among children compared to older adults, is still a problem. Almost 700 children have died from COVID-19 in the US so far. While this might seem to be similar to a normal flu season where between 34-200 children die during a given year, keep in mind that these numbers are affected by flu vaccinations that are given to children every year. Flu shots are widely available to all kids, while no COVID vaccines have been authorized for children under 12. More than half of children, around 60%, get their flu shot each year. This significantly reduces the death rate for children who are vaccinated since the vast majority (~90%) of kids who die from the flu each year are unvaccinated. That means, if you compare apples to apples, the flu death rate for children would be much higher without the annual flu vaccine – which is the reason why a flu vaccine for children has been made available. Why then should we not make a COVID vaccine available for children as well?

“Among children age 1-14, COVID-19 was in the top 10 leading causes of death through August and September 2021. Among children age 5-14, COVID-19 ranked as the number 6 leading cause of death in August and September. Among children ages 1-4, COVID-19’s rank rose from number 13 to number 7 among leading causes of death in August 2021 and held there in September.” (Link)

As far as the known risks of vaccines for children, these risks are still far less than the risks of getting infected by the live virus – for every significant risk one can list.

It is for this reason that the FDA advisory panel unanimously voted, yesterday, to approve the reduced dose Pfizer vaccine for children ages 5-11 (Link).


Why Vaccinate Kids Against COVID-19?
Although rare, it is thought that the production of the spike protein, from cells translating the mRNA vaccine, can trigger the same inflammatory cascade as a COVID-19 infection, resulting in these neurotrophic effects such as seizures (Link, Link). In children, seizures following various kinds of vaccinations may be related to the development of fevers (Link). Such febrile seizures do not end up affecting a child’s development or behavior (Link). It may also be that certain individuals are more prone to this side effect.

It is also interesting to note here that seizures may be the first and main manifestation of COVID-19 in children. “Seizures may occur even in children with no history of epilepsy and in the absence of fever or severe COVID-19 illness, necessitating a ‘high index’ of suspicion for the virus to make an early diagnosis and allow for appropriate infection control measures… Among 175 children diagnosed with acute SARS-CoV-2 infection in the emergency department over 10 months in 2020, 11 (6%) presented with seizures. Studies in adults with COVID-19 have reported seizures in 0% to 2% of cases, the investigators note. The 11 children with seizures (seven boys) ranged in age from 6 months to 17 years (median age, 11.5 years). All of them had seizures as the presenting sign of infection and none had severe COVID-19 requiring ventilatory or hemodynamic support. Six of the 11 children presented with fever.(Link).


Recent Comments by Sean Pitman

Dr. Aseem Malhotra: From Pro-Vax to Anti-Vax
Freedom of choice and being opposed to vaccines are two different issues. The fact is that Dr. Malhotra is strongly opposed to the mRNA vaccines against COVID-19, claiming that they are far more harmful than beneficial. That clearly makes him anti-vax. He’s not just arguing for personal freedom here, he’s directly arguing against the vaccine itself as being dangerous since he claims that it caused his own father’s heart attack. The problem is that the weight of scientific evidence doesn’t support Malhotra’s anti-vax claims.

Now, I’m happy to support your personal freedom to believe and do whatever you want to believe and do – as long as it does not substantially increase the risk of those around you. However, when it comes to spreading falsehoods and outright lies against the mRNA vaccines, I’m going to speak out against that and call it what it is – sensational nonsense being spread by those who are opposed to vaccines based on nothing more substantive than personal emotions. That’s just not a good basis for determining “standard of care” for medical practice.


Dr. Walter Veith and the anti-vaccine arguments of Dr. Geert Vanden Bossche
Natural immunity is great! In fact, natural immunity alone prevents approximately 10% of the population from becoming ill from all of the variants of COVID-19. The problem is that for a great many people, especially people older than 50, natural immunity just isn’t enough to prevent serious sickness and even death. The claim that the mRNA vaccines make people “more susceptible” simply isn’t true. While one can still get infected after vaccination, mRNA vaccines have clearly proven their ability to dramatically reduce the risks of serious illness from infection with a dramatic reduction in the rate or percentage of those who are vaccinated being hospitalized or dying (compared to those who are not vaccinated). Also, those who are vaccinated suffer much less severe long-term effects from infection.

In short, the overall risks of getting infected by COVID-19 are significantly greater, regarding any type of serious risk, as compared to getting vaccinated with the mRNA vaccines against COVID-19 – and these benefits of vaccination become greater and greater with age since natural immunity naturally declines with age.


Dr. Aseem Malhotra: From Pro-Vax to Anti-Vax
The strong anti-vaxx stance of many Adventists has been a big surprise to me as well! I just don’t get it. We’re supposed to be strong supporters of good cutting-edge advances in medical science…


Dr. Aseem Malhotra: From Pro-Vax to Anti-Vax
I think it’s even less common than that. However, when my boys were vaccinated, we did have the techs pull back on the syringe both times (Link). Myocarditis occurs about twice after every 100,000 injections. On top of that, research shows it’s typically mild and resolves quickly (Link).


Dr. Aseem Malhotra: From Pro-Vax to Anti-Vax
Maybe rarely…