Oh please. The Elgazzar paper, by itself, accounted for …

Comment on Dr. Peter McCullough’s COVID-19 and Anti-Vaccine Theories by Sean Pitman.

Oh please. The Elgazzar paper, by itself, accounted for 15.5% of the effect of the meta-analysis paper. Remove that and you basically remove the statistical significance of your meta-analysis paper.

Of the other papers used in the meta-analysis, many relied on small sample sizes or were not randomized or well-controlled. And in 2020, an observational study of the drug was withdrawn after scientists raised concerns about it and a few other papers using data by the company Surgisphere that investigated a range of repurposed drugs against COVID-19. “We’ve seen a pattern of people releasing information that’s not reliable,” says Hill. “It’s hard enough to do work on COVID and treatment without people distorting databases.” (Link).

“I personally have lost all faith in the results of [ivermectin] trials published to date,” says Gideon Meyerowitz-Katz, an epidemiologist at the University of Wollongong in Australia who helped Lawrence to analyze the Elgazzar paper. “It’s not yet possible to assess whether ivermectin works against COVID-19 because the data currently available are not of sufficiently high quality,” he says, adding that he is reading other ivermectin papers in his spare time, looking for signs of fraud or other problems. (Link)

Chaccour and others studying ivermectin say that proof of whether the drug is effective against COVID-19 rests on a handful of large, ongoing studies, including a trial in Brazil with more than 3,500 participants. By the end of 2021, says Zoni, around 33,000 people will have participated in some kind of ivermectin trial. (Link)

And, another recent meta-analysis study by Roman et al., which did not include the Elgazzar study, showed no beneficial effect. (Link)

That’s the reason why larger double-blinded placebo-controlled trials are seen as more reliable, generally speaking, compared to meta-analysis papers – which is why the preliminary results from the large “Together Trial”, and even the smaller Lopez-Medina trial, seem far more convincing to me.

Now, if you want to keep going after possible conspiracies, fine, but that’s not good evidence in support of ivermectin as a useful therapy against COVID-19.

Sean Pitman Also Commented

Dr. Peter McCullough’s COVID-19 and Anti-Vaccine Theories
Fetal cell lines, originally produced decades ago, were used in the testing of the mRNA vaccines – as they were in the testing of Tylenol, Motrin, Robitussin, Aspirin, Sudafed, Tums, Lidocaine, and a host of other modern medications that most people use on a semiregular basis (Link).


Dr. Peter McCullough’s COVID-19 and Anti-Vaccine Theories
I see no evidence that the published ingredient lists for the mRNA vaccines are not transparent and factual. There just is no credible evidence for “graphene” in these vaccines and fetal cell lines simply aren’t necessary to produce these types of vaccines.


Dr. Peter McCullough’s COVID-19 and Anti-Vaccine Theories
The hospitalization/death rate is far less for the vaccinated vs. the unvaccinated (Link). Note, in this line, that those states with the lowest vaccination rates have the highest death rates per capita:

As far as natural immunity gain via a prior COVID-19 infection, it can actually be superior to the immunity gained via full vaccination. However, natural immunity is less predictable. Up to a third of people who were previously infected by COVID-19 don’t develop antibodies against it (Link). However, if one can demonstrate an adequate level of antibodies against COVID-19 it seems reasonable to me that such people should be considered to have adequate immunity.

As far as the immunity generated by vaccination, the type of immunity generated would not be so effective at preventing a mucosal nasopharyngeal infection since the types of antibodies produced (IgG and IgM) would preferentially be blood-based rather than tissue-based (IgA) type of immunity (Link). Because of this, naturally derived immunity might have an additional advantage in this regard as well.


Recent Comments by Sean Pitman

Mandates vs. Religious Exemptions
I’m just saying is that if you think that what you say on blog sites like this one doesn’t really affect people, especially when you present yourself as an MD, you’re mistaken. I know that people have been influenced against taking the mRNA vaccines by what you’ve said here in this forum. You’re not simply being neutral in what you’ve posted. You do, in fact, come across as being opposed to the mRNA vaccines – also noting that you didn’t get vaccinated yourself and chose to get infected by the live COVID-19 virus without pre-established vaccine-based immunity. You’ve also come across as being strongly against any response by me to the articles that you’ve referenced where I point out how these papers really do not actually undermine the efficacy and/or the relative safety of the mRNA vaccines. Clearly, you don’t come across as being neutral on the topic.

And, such comments have an effect on people – they really do. While that upsets me, again, it’s more important to me to allow for those who disagree with me to also post their comments rather than to only allow what I personally think is true to be posted.

Beyond this, no one is twisting your arm to post our comments here. You can post or not post as you wish. That’s entirely up to you. But, don’t expect that I won’t push back when you post comments that I think will increase the risk of those who read what you have to say…


Mandates vs. Religious Exemptions
The difference between us is that I see people in the ICU, as does my brother-in-law Dr. Roger Seheult (a pulmonologist in S. Cal.). You might see the occasional person die from COVID-19, but those who work ICUs in larger medical centers see far too many people die from COVID-19 – to include young people (not just those in nursing homes). You might offer the vaccine to those whom you see, but if you present arguments to them like the ones you’ve presented here, such advice most certainly does result in increased injuries and even death. For me, that’s a big deal. You might call it “weird and overly dramatic” if you want, but for me the effort to save lives and reduce injuries is neither “weird” nor “overly dramatic”. I mean, that’s why I do what I do…

Now, you say, “The discussions that I have on blogs like this are my personal thoughts and concerns. They don’t reflect the way that I actually practice primary care medicine on a daily basis.”

That would be great if this were a private conversation, but it isn’t. It is a public conversation and your words have an impact on the hundreds who read this blog every day. I mean, in a very real sense, especially given that you include your title “MD” with your name, and often point out that you are a medical doctor when you post to this blog, you are, in fact, practicing medicine when you post public comments like you do. You cannot simply say, “I don’t actually follow my own advice that I post in blogs when I practice primary care medicine on a daily basis.” Your influence simply isn’t limited to what you do face-to-face with patients in your clinic. Your influence also extends to what you say and do in front of people outside of your daily medical practice.


Mandates vs. Religious Exemptions
Well, I’m glad you go at least this far… although I still think that the kinds of arguments you present here really do put people’s lives and health at increased risk. I know you don’t agree, but that’s how I see things from my own perspective.

Now, I’m fine with you, and those who think like you, having the ability to freely share your opinions – despite how mistaken and damaging I personally think these opinions may be. That’s just the nature of living in a free society – which I think is far more important than restricting the freedom of speech.


Mandates vs. Religious Exemptions
Yes, I’ve been reviewing these particular evolutionary arguments for over 20 years myself: Link, Link

Again, however, when it comes to active retrotransposons in normal human cells, naturally, the expression of LINE sequences is repressed in most cell types. Its RNA is mainly heritable during early embryogenesis because of its enrichment and high retrotransposition activity in early embryos (Grow et al., 2015). That’s why the Swedish research team used a tumor cell line where LINE-1 sequences where more strongly expressed.

On the other hand, it does seem to be true that cells infected by live SARS-COV-2 viruses do show enhancement of expression of retrotransposons:

In our study, we analyzed publicly available transcriptome data of human cells infected with coronavirus MERS-CoV, SARS-CoV, and SARS-CoV-2, and observed enhanced expression of TEs including several retrotransposons, as well as inflammation, immunity, and apoptosis related genes. We further noticed potential fusion of SARS-CoV-2 RNA with retrotransposon transcripts especially LINEs and SINEs… One of the major mechanisms for LINE-1 silencing is DNA methylation, and we examined expression of genes encoding DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) enzymes mediating active DNA demethylation. We observed that Tet genes were generally upregulated after coronavirus infection (Figure 2D), and upregulated DNA demethylation activity may lead to demethylation of retrotransposon promoters. This result supports that increased retrotransposon expression was caused by genome-wide DNA demethylation. We obtained similar results in MERS-CoV/SARS-CoV infected MRC5 cells which are noncancerous human lung fibroblast cells (Figures 2A–D)… SARS-CoV-2 infection also causes upregulation of TET gene expression (Figure 2D). Similarly, SARS-CoV-2 was identified to have the capability of infecting human intestinal organoids (Figure 2E) and increased retrotransposon expression can also be observed post infection in a time-dependent manner (Figure 2F)…

Coronaviruses are RNA viruses and are not supposed to integrate into host genome by themselves. However, it was reported that several RNA viruses have capacity to recombine with retrotransposons to invade host genome (Geuking et al., 2009)… This demonstrates high efficiency of LINE family especially LINE-1 in forming chimeric transcript with SARS-CoV-2 RNA. LINE-1 is autonomous retrotransposon with retrotransposition activity, and RNA-RNA ligation mediated by endogenous RNA ligase RtcB was previously reported for LINE-1 to carry other types of RNA for host genomic invasion (Moldovan et al., 2019), so similar mechanisms may apply for SARS-CoV-2 transcripts. Further examination of human genome from SARS-CoV-2 infected human cells or biopsies will be particularly important to identity existence of integration of coronavirus RNA into human genome.
(Link)

So, you see, if anything, infection by live SARS-COV-2 viruses puts a person at higher risk of cellular genetic modification compared to the mRNA vaccines. This only adds to the reasons to get vaccinated against COVID-19 rather than to gain “natural immunity” the hard way – i.e., via a live SARS-COV-2 infection. Yet again, the risks are simply far higher here for the natural infection vs. vaccination.


Mandates vs. Religious Exemptions
I think everyone’s knowledge of retrotransposons is limited when it comes to how they might possibly pose any kind of real risk for the use of mRNA technology – for vaccines or any other use. If you think otherwise, by all means, do share with me how retrotransposons reasonably create such a risk? This paper from Sweden that you’ve most recently forwarded certainly does no such thing.

As far as what kind of “weight of evidence” it would take to change your mind about mRNA vaccines, you say that you don’t require “absolute knowledge”, but it certainly seems as though you’re raising the bar far far higher than is reasonable – to the point of preferring to get sick with a COVID-19 infection, putting yourself at a far higher risk of long-term injury and even death, rather than take an mRNA vaccine. Given the evidence that is currently in hand, I find that position to be rationally untenable – especially when it comes to trying to convince others to do the same thing during a time when those who are getting very sick and dying, still thousands every day, are almost all unvaccinated.

Now, I’m glad that you personally survived, but spreading misinformation like this has cost and is still costing many lives. I have a problem with that and I do not at all apologize for my strong recommendation that pretty much everyone who has access to the mRNA vaccines get vaccinated against COVID-19.