I have given you references to real studies with data …

Comment on Southern Adventist University opens Origins Exhibit by Sean Pitman.

I have given you references to real studies with data that indicate that 2 animals is unquestionably a non-viable populations in any conservation breeding program which is the best we have in terms of replicating the ark scenario.

Not only have modern breeds of dog been based on very limited numbers of breeding pairs, this experiment has been repeated with foxes (see nova video linked above).

Beyond this, as already explained, your arguments are entirely based on gene pools that have built up large numbers of detrimental mutations. Mammalian gene pools, as with all other slowing producing creatures, are heading downhill. That is why the ancestral parental gene pool was much better off than it is today. You really have no rational basis to argue otherwise beyond your dedication to neo-Darwinism. The evidence of genetic deterioration far faster than natural selection can keep up with it is quite clear for all slowly reproducing creatures.

Further I have suggested that doing the math does not allow one to even conceive of vast phenotypic potential on the basis of allelic variation in a population of 2.

Oh really? I’ve yet to see you do much of any math. What math are you talking about that significantly limits the phenotypic trait potential of a breeding pair of wolves? – to a point where similar phenotypic diversity, on a practical level, could not be achieved without a basis in novel mutations?

You continue digging the hole by deprecating the role of new mutations and insisting that there is front loaded potential by a mechanism you cannot define in accepted genetic terms.

The role of new mutations is largely detrimental/degenerative – as you should know. I’ve listed examples of such in this same thread. Occasionally, of course, certain benefits do arise by novel mutations, but not beyond very very low levels of functional complexity – as I’ve also explained.

Having raised the issue of polygenic nature of phenotypic traits as an explanation of the vast potential I thought you would be familiar with some of the more foundational concepts in genetics. From your responses I once again seem to be in error. What is the conventional view.

The current concept of a gene is of a sequence of DNA in the genome that codes for a protein and has associated regulatory elements and non-coding RNA.

Pretty good, except for the fact that the modern concept of a “gene” or functional genetic element has been expanded by the discovery that protein-coding genes do not contain the majority of functional information within the genome. “Non-coding genes” occupy the majority of the genome and control the “coding” genes as a blueprint dictates how the bricks and mortar are to be applied in the construction of a building.

But anyway, I digress…

The organism at the level of the organelle cellular, organ, or organism is sustained by biochemical pathways and structures that rely on these genes.

Depending on levels of redundancy loss of a gene may affect the function and result in a particular change in the organism which is recognized by observation grossly biochemically or microscopically. This is often called a trait as in sickle cell trait or phenotype where there is a particular shape of the red cells. Usually this there are multiple characteristics associated with this trait. For Sickle cell disease this is rapid clearance of the red cells from the blood and anaemia. Trouble with red cells in the circulation leading to blocked blood vessels and resistance to malaria infection of the red cells.

So far so good . . .

Mendelian traits are those that map to a single gene locus and result in a phenotypic change. Sickle cell is one that maps to a gene coding for part of the haemoglobin molecule.

Right . . .

Now production of red cells containing haemoglobin red cells is dependent on very many genes. From the genes such as eythropoietin that regulate amount of haemoglobin and red cells that are produced in erythroblasts and progeny cells in the bone marrow to the genes controlling the proteins and carbohydated structure of the red cell membrane all are related to the red cell physiology and physical characteristics or phenotype.

That’s right . . .

Now say a population of people move to the Himalayas or the Andes. They need more red cells. The response will be that those in the population that have the best ability to produce red cells will have better ability to carry oxygen in the presence of low oxygen tension and will have better fitness. This trait of high altitude fitness is unlikely to be a mendelian train but will be a polygenic trait. The initial measure of ability to carry oxygen will have something like a Gaussian distribution. If there is within the population multiple genes with some polymorphism or variability in function even through within that one gene it has minimal overall effect the selection will be on multiple such genes so that the fittest population with the high oxygen carrying phenotype will have a genotype that is has been selected for the phenotype. It is a not a selection of genes one at a time but a simultaneous selection. Allele frequency at multiple loci will be changes within a very short time. Now if one of the people in the population has a new mutation that has better function it will be quickly fixed in the population and carried along with a cluster of more or less useful genes. In other words selection integrated across a large number of genes.

Also true . . .

To argue about potential sequence space and absolute probabilities is nonsense.

How so? How do you determine the odds that any novel system of function, where all of the amino acid residues must work in a specific arrangement with each other, will be realized in a given span of time by random mutations? The fact is that you don’t make this determination at all. You don’t consider the math or the odds at all. You just assume that it happens without considering the level of functional complexity involved with finding novel beneficial sequences in sequence space.

This concept I would have thought was familiar to you as even Sanford in his book “Genetic entropy” does accept there is phenotypic rather than genotypic selection (see chapter 4 and his cute Princess and the nucleotide paradox).

Of course this concept is familiar to me. It is a correct concept. There is phenotypic selection that affects the underlying genotype. I’ve already gone into this before with you, if you will recall. Your problem is that you do not consider the level of functional complexity involved. Low-level systems can and do evolve all the time. However, as you consider higher and higher levels of qualitatively novel functional complexity, the evolvability of these higher level systems drops off – exponentially.

What Sean is arguing is that things like size and coat colour in Dogs that are clearly polygenic the cis interactions between mjultiple variable genes can compensate for a lack of polymorphism at any genetic locus imposed by a population size of 2.

That’s right.

If we assume that dog size depends on products of pathways involving 5 genes [in fact this is vastly overestimating it as IGF-1 seems to be the predominant determinant], then in a population of 2 there are maximum of 4 alleles at 5 loci. The possible genotypes assuming absolutely no genetic linkage are then 4^5 = 1024 compared to 20^5 = 3.2 million for a population of 20 with the same level of genetic heterogeneity and allelic variation.

A population of 2 with complete heterogeneity over 5 loci is not what is seen in extant populations; but allowing Sean’s assumption in any lottery I would take my chance with 3 millions rather than 1000 tickets.

As already noted, size in dogs is primarily controlled by six genetic regions and dozens of genes with lesser influence (compared to humans were height is governed by >200 genes). The sequence space is 4^6 = 4096 based on just these six primary controls for size alone (not counting the dozens of other genes that are involved in more minor ways here). This seems like adequate control for this particular trait. How much more control over size one would want I don’t know?

You seem to be totally confusing a polygenic family and a polygenic trait.

How is that?

The MHC is not a phenotype or a function. It is a region of 2 megabase or more contains a family of genes, likely of common origin, in tight linkage dysequilibrium and in which the different loci can be ascribed particular functions.

The Major Histocompatibility Complex (MHC) is indeed a collection of different types of proteins that are collectively involved with appropriate immune system function – a polygenic trait. Are the different elements of the MHC complex individually selectable? Certainly . . .

HLA-B codes for the alpha chain of class I molecules. This encodes the CDR region of the molecule that is the site that can bind to specific 9-11 amino acid peptides that have a structurally complementary sequence to the class I alpha chain. The high levels of polymorphism at this locus determined the phenotype or what will bind to that molecule and be recognized by a CD8 or cytotoxic T cells. This is the phenotype that is subject to selection; the allele that can recognize a particular pathogen structure.

Yes . . .

Presence of the allele HLA*B57 has a clear survival advantage in HIV infection by recruiting particularly effective CD8 T cells that recognize that class I molecule. The HLA*B5701 haplotype as well as 5702 and 5703 and the related 5801 all have ability to create effective HIV specific CTL that determines the good responder phenotype not because of the associated changes outside the peptide binding groove or nucleotide variation elsewhere in the gene that defines the 4 digit specificity.

Right . . .

Geneticist do not see any qualitative difference between allelic variation and mutation except in frequency within a population. There is absolutely no reason to conceptualize some distinction between changes in nucleotide sequence because of some imagined ancestory. It is up to you to provide a model and evidence if you wish to do so.

Again, I’m not sure what you’re your main point is here? Of course mutations produce allelic variations! Where have I even suggested otherwise? In fact, some systems, especially immune systems, are based on the programmed production of genetic variations to produce a huge variety of antibodies (before non-self antigens are even encountered).

It is just that random mutations do not produce qualitatively novel systems of function beyond very low levels of functional complexity is all. That’s the main point here. This is the point that you’re simply not addressing in any of your responses thus far.

Also, what do any of your arguments have to do with my statement that the current phenotypic variety of animals is largely based on pre-programmed or “front-loaded” information? – that many current allelic options are detrimental or degenerative in nature? – or that there are no examples of qualitatively novel functionality beyond very low levels of functional complexity arising by RM/NS?

I look forward to reading you PLOS one or PLOS genetics paper on the recognition and importance of mutations with “very very low levels of functional complexity”.

I do not dispute the impact or even the importance of mutations with low-level functional effects. That’s not even in question here. Such mutational effects can and do happen – very commonly in fact in larger populations. That is why it doesn’t require long periods of time for such mutations to be realized. What cannot be explained by you or anyone else coming from a Neo-Darwinian perspective is the origin of qualitatively novel systems of function that require a minimum of more than 1000 specifically arranged amino acid residues.

Sean Pitman
www.DetectingDesign.com

Sean Pitman Also Commented

Southern Adventist University opens Origins Exhibit
@pauluc:

If I may summarize our previous posts on allelic variation, SNPs and speciation
You suggest

1] There was frontloading of genetic information in a breeding pair for most species 2349-2348 BC.

The frontloading was at the time of creation by the Creator (less than 10,000 years ago), with a genetic bottleneck at the time of the Noachian Flood some 4,000 or so years ago . . .

2] Variation leading to speciation within kinds was by genetic mechanisms of allelic variation from the original gene pool. Maybe 10-20% of the variation can be attributed to this front loading.

It depends what type of variation you’re talking about. All of the variation beyond very low levels of functional complexity is the result of frontloading . . .

3] Most of the allelic variation and SNPs seen in species today has arisen by random mutation within the populations derived from this starting population of 4 haplotypes. ie 80-90% of the variation within species derived from “kind” ancestor.

At low levels of functional complexity, yes, the vast majority of allelic variations are the result of random mutations.

4] Most (80-90%) of the phenotypic differences seen between species has occurred by natural selection and genetic drift.

Within the same basic “kind” of gene pool – yes.

5] Any differences due to RM/NS after selecting the front-loaded pair can only confer very very low level complexity.

That’s right.

6] There is a barrier of 1000fsaar that limits any ability to generate anything novel and complex within this 80-90% of new mutations.

Yes.

Apropos of the recent paper:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310774/?tool=pubmed

How do you modify your model of constraint by 1000fsaar to account for the role of SNPs in determining the effects of non-coding regulatory elements? In this context any discussion of hamming distance is really examining the edge effect of minimal relevance. I should not have to explain how this is particularly germane and impacts your discussion about genetics of feathers and the regulation of genes controlling feathered phenotype.

Non-coding regulatory elements are key to the building of complex systems within living things – far more important than are the protein-coding genes themselves (which function more like bricks and mortar that can be used to create many different types of buildings). SNPs can affect these regulatory elements, obviously. However, SNPs cannot affect these regulatory elements in a way that causes them to produce a qualitatively novel type of “building” with the “bricks and mortar” – beyond very low levels of functional complexity of course. In other words, you have to ask yourself the odds that a single point mutation to a regulatory non-coding sequence, or any other type of mutation, will result in a change in the location of the final product to an entirely novel island in sequence space that has a qualitatively unique function that requires a minimum of more than 1000 specifically arranged amino acid parts? That just doesn’t happen. There are no examples of this anywhere in literature – period.

If you would actually sit down and do the math, you’d see why. Sequence space has a fairly uniform distribution of potentially viable sequences/structures. As the minimum size and or specificity of the system under consideration increases in a linear manner, what do you think happens to the ratio of potentially viable/beneficial vs. non-viable/non-beneficial sequences in sequence space? The number of non-viable sequences increases in an exponential manner compared to the potentially viable sequences. The means that the viable sequences become more and more isolated in sequences space, dramatically so, with each step up the ladder of minimum size and/or specificity requirements. This means, of course that the minimum likely gap distance between viable sequences in different island clusters increases in a linear manner with each increase in the minimum size and/or specificity requirements. And, this means, of course, that the average time needed for any kind of random mutations needed to traverse the linearly increasing gap distances increases exponentially.

Now, tell me, how do you solve this sequences/structure space problem at increasing levels of functional complexity? Do you really not see the exponential nature of the problem? There is really no point in further discussion if you will not discuss this particular question. I really don’t understand your continued reluctance to substantive address such problems or consider the statistical basis for your own evolutionary assumptions. Why don’t you sit down and actually do a few calculations? Why not calculate the odds, for yourself, of any kind of mutation or series of mutations in any kind of coding or non-coding region evolving any kind of qualitatively novel system at various levels of functional complexity?

Give it a shot already. What could it hurt?

Sean Pitman
www.DetectingDesign.com


Southern Adventist University opens Origins Exhibit
@pauluc:

Since you havent responded to my request to identify in the genomic comparison of mammalian species or primates with the instances of where the 1000fsaar criteria limiting the sequence differences, I suggest an alternative.

But I have responded to this question at least a couple times in this thread. Please go back and review these responses to you and Jeff Kent.

Please provide insights on this recent paper from Kate Sullivans group on Human Accelerated Regions that are proposed to be contributors to the differences between humans and Chimps particularly in limb and brain development. Im interested in the comparison between human SNPs and the varying presence of these SNPs in chimp, Neandertal and Denisova genomic sequences.

Differences between human and ape brain development are based on more than SNPs (which would produce quantitative differences in form and function, but not produce qualitative changes beyond very low levels of functional complexity).

As already noted a few posts above in this thread, humans and apes are quite different in various respects, to include brain structure and function – which is thought to be based on numerous differences in genetic regions that code for miRNAs (around 8% of which are human specific).

“miRNAs recently have been implicated in synaptic development and in memory formation. As the species specific miRNAs described here are expressed in the brain, which is the most complex tissue in the human body, with an estimated 10,000 different cell types, these miRNAs could have a role in establishing or maintaining cellular diversity and could thereby contribute to the differences in human and chimpanzee brain … function.”

Eugene Berezikov, Fritz Thuemmler, Linda W van Laake, Ivanela Kondova, Ronald Bontrop4, Edwin Cuppen & Ronald H A Plasterk, “Diversity of microRNAs in human and chimpanzee brain”, Nature Genetics, Vol 38 | Number 12 | December 2006 pp. 1375-1377.

The Y-chromosome is even more unique. A study published by Nature in early 2010 showed many striking differences between human and chimp chromosome structure, gene content, and even qualitatively unique genes between the two species.

As far as looking at specific genes, the chimp and human Y-chromosomes seem to have a dramatic difference in gene content of up to 53 percent. In other words, the chimp is lacking approximately half of the genes found on a human Y-chromosome. Because genes occur in families or similarity categories, the researchers also sought to determine if there was any difference in actual gene categories. They found a shocking 33 percent difference. The human Y-chromosome contains a third more gene categories, entirely different classes of genes, compared to chimps.

Hughes, J.F. et al. 2010. Chimpanzee and human Y chromosomes are remarkably divergent in structure gene content. Nature. 463 (7280): 536-539.

For further discussion see:

http://www.detectingdesign.com/pseudogenes.html#Key

I am sure you see P Troglodyes as entirely unrelated to man but I am a little unclear on your model of origins in terms of relatedness of Neandertal and Denisova hominids to man. Are they the children of Adam, Noah or neither? How do you account for any sharing of SNPs, the HAR and the development of pehnotypic differences by SNPs?

Neandertals and Denisova are human, descendants of Noah. They are simply ethnic variations of humans. Even mainstream scientists think that they could interbreed with each other to produce viable and virile offspring.

Of course there will be SNP differences between modern humans and Neandertals and other ancient ethnic groups – as there are between modern ethnic groups. And, these SNPs may be associated with functional differences – but not beyond low levels of functional complexity (usually only quantitative differences of the same basic type of gene function).

As far as the HAR-1 RNA, there are 18 character differences between humans and chimps (out of 118 characters/nucleotides). These differences are thought to play some role in the development of our brain differences, but no one knows exactly what role. Obviously, there are many structural and functional brain differences at high levels of functional complexity. However, there are also many unique non-coding genetic elements that seem to be involved with these differences (as already explained). No single point mutation or small cluster of mutations is going to be able to cross the gap between any qualitatively novel higher level system of function. Again, there are no examples of this in literature – for very good statistical reasons.

Another paper that cries out for your interpretation including the point at which ignorance about the 1000fsaar limit has blinded this group of scientist.

http://www.ncbi.nlm.nih.gov/pubmed/22398555

Critique below the abstract would be most helpful in seeing the errors.

Where in this paper is there any discussion of levels of functional complexity and how mutations can generate qualitatively novel systems at high levels of functional complexity? Remember, we aren’t just talking about quantitative differences in functionality here. We are talking about qualitatively novel differences beyond low levels of functional complexity. We need some actual math here – a few statistical calculations as to the odds that the just-so stories in papers like this might or might not actually be likely to be realized in a given span of time. Please do quote for me the relevant portion of this or any other paper along these lines.

Don’t just give me a bunch of references without any quotes or commentary (aka: reference mining). Show me that you actually understand the problem under discussion by, well, discussing it for a change with the use of quotes that you think are relevant. That would be most helpful…

Sean Pitman
www.DetectingDesign.com


Southern Adventist University opens Origins Exhibit
@Professor Kent:

Again, the question is why does one accept the Bible among so many compete options as the real Word of God? If this choice is based on blind faith without any rational basis or appeal to the weight of empirical evidence, what you have is nothing much more useful than wishful thinking… not the kind of faith that has the power to provide a solid hope in the future for most rational people – especially in the face of very difficult trials or even the threat of torture and death.

What you’re asking people to do is to accept the Bible without really considering the weight of empirical evidence or any additional evidence that may contribute to the current weight of evidence for or against the Bible’s credibility. That’s simply not a rational expectation. Certain God does not expect anyone to believe without a rational basis for belief or faith set upon the weight of evidence that would appeal to the candid mind.

In this line, we are talking about what paid representatives of the SDA Church are teaching and/or preaching in the name of the Church. The Adventist Church, as an organization, simply cannot afford to pay people to go around teaching our young people that the best we have to support the Adventist position on origins is faith that is effectively blind to the otherwise overwhelming scientific basis for neo-Darwinism. That simply isn’t helpful to Adventism. Those who believe in neo-Darwinism, however honest and sincere they may be (and there are many in this category) cannot effectively represent the Adventist perspective on several fundamental doctrinal positions within our schools…

Sean Pitman
www.DetectingDesign.com


Recent Comments by Sean Pitman

Updating the SDA Position on Abortion
Obviously, I’m not talking about women who don’t understand how IUDs and hormonal birth control work. I’m talking about women who do understand. And, according to your cited reference, the majority of women who have such knowledge would not stop using such forms of birth control. Given your position that full human life begins at the moment of conception, such fully-informed women would most certainly be guilty of pre-meditated first-degree murder – before God. Again, morally speaking, it doesn’t matter at all what a human government may or may not say or do. Human governments don’t determine true morality. What really matters is what God thinks. Are such fully-informed women murderers before God? The same as a woman who kills her baby at full term? – just before it would otherwise be born naturally? That’s my question here. I could not make the accusation of murder against a woman using hormonal birth control or IUDs because there really is no unambiguous Scriptural support for your position that full human life begins at the moment of conception – as far as I’m able to tell. That’s the bottom line here.

As far as your argument that the word Gabriel used for John the Baptist before he was born was the same as for a baby that had been born (supporting the equal moral value of the unborn), the Greek that Gabriel used here was: βρέφος. Notice, however, that Gabriel did not use this particular word until John was already six months old (Luke 1:36-41). So, again, as previously discussed with you, I fail to see how Gabriel is defining John as a full human being from the moment of conception here.

After all, an early embryo can split in two, or three or four or five embryos – ending in identical offspring. Yet, although genetically identical, each baby produced in this manner is a unique person. Twins may have identical genetics and indistinguishable bodies, yet they are uniquely different people before God. When did the unique identify of each of these identical twins or triplets, etc., begin? Clearly, not at the moment of conception. You see, the creation of unique genetics isn’t the same thing as the creation of a unique soul or individual person.

You say that I’m unable to provide Scriptural evidence for the dichotomy between the moral value of a person and “its nature”. Well, where is your definitive Scriptural evidence in support for a single cell or small clump of a few cells being fully human? As a relevant aside, where does the Scripture talk about “brain death”? Yet, we do not consider it “murder” or even “manslaughter” to “pull the plug” or harvest the organs of someone who is definitively brain dead – even if the rest of the body is still alive. Why is that do you think? Obviously, because there is no “false dichotomy” here even though Scripture doesn’t specifically address such a situation. The same could very reasonable be true of the human embryo as well. There simply is no definitive Scripture otherwise as far as I can tell.

As far as the LXX, Masoretic, and DSS all “agreeing”, with you I presume, regarding Exodus 21:22-25, well, I just don’t see it that way – and neither do many others, to include many well known historians and Christian leaders and thinkers. There has been a widespread and nuanced theological debate about the beginning of life in the history of Christianity. The idea that personhood begins at the moment of conception is far from a universally agreed upon matter of historical Christian doctrine. When viewed in the long history of the Christian tradition, it is the minority position. In any case, Exodus 21:22-25 does read differently in the LXX and none of the translations seem to definitively support your position. Ancient Jewish scholars certainly didn’t take your perspective. Since the death of a person would be murder or manslaughter, and carry a different penalty, most rabbinic sources deduce from these verses that a fetus has a different status. The Babylonian Talmud states that: “The embryo is considered to be mere water until the fortieth day.” So, I’m afraid that the “weight of evidence” is not clearly on your side here – at least not as best as I am able to tell. Certainly nothing in the New Testament definitively clears up this question in your favor.

The other names your mention present no more convincing arguments than you present – as far as I can tell. They may be less abrasive in their approach (certainly Nic is a very kind and tenderhearted man), but the basic arguments used are very similar to those forwarded by Andrew – just not convincing to me despite my honest efforts to carefully consider them as best as I am able.

Now, it is interesting to me that you actually argue that my position on abortion, “my own definition”, is clear enough to indict those who have committed late-term abortions of murder. If so, I fail to understand your argument that I’ve said and done “nothing” here to make my position clear to the church. The leadership of the SDA Church is well aware of my position.


Updating the SDA Position on Abortion
Andrew’s response (Link):
____________

Please notice that by Dr. Pitman’s own argument his very own Adventist Church supports the murder of the unborn (see @25:01) yet notice in his response that he completely ignores this. The Adventist Church, to which Pitman belongs, supports the violent torture and murder of boys and girls in utero yet Pitman spends his time criticizing……Prolife Andrew. To use an analogy, if you belonged to a church that supports rape or slavery why would you then complain about another church member who opposes this? Pitman complains that Andrew is “needlessly abrasive in his tone” but, to further the analogy, at least Andrew doesn’t support rape or slavery! Apparently, an abrasive tone is worth more criticism than supporting or practicing murder. My video is vindicated.

A few additional points:

1.
Pitman does everyone a favor by openly proving the point. He says “Surprisingly, Andrew would evidently be fine with a “lesser charge” such as “involuntary manslaughter” RESPONSE: As was explicitly stated in the video @15:29 onwards it was stated “government to make illegal the manufacture sale and use of chemicals that are used to kill or do kill other human beings Dr Pitman however completely ignores this.” And how does Pitman respond? By doing exactly that, ignoring this fact. Andrew’s opinion is irrelevant to the premise of the argument which Pitman ignores: The government can protect the right to life. It can charge people with crimes for destroying an innocent life. The degree of the crime and one’s culpability is determined by the government, not by Andrew. Pitman, again, just ignores the argument. (See also the video @56:29 onwards).

2.
In his response under the video Pitman says “It’s like arguing that deliberately putting lethal poison into apples or candy or medication at the supermarket isn’t really premeditated murder because the one doing this doesn’t know exactly when someone will actually die. That argument is clearly false on its face.” This is another falsehood because Pitman is confusing (1) birth control pills that prevent implantation with (2) injecting poison into supermarket foods. The big difference between the two is knowledge. In the former most women have no idea how contraceptives work. The vast majority of women who take contraceptives do so ignorant of how they work while, in Pitman’s example, injecting poison relies upon knowledge. Most women do not know how contraceptives work and if they did know it would change their behavior. For example, in 2010 a journal for obstetrics and gynecology reported that 45% of the women said that they would not consider using a birth control method that had post-fertilization effects, and 48% of women said that if they found out they were using a method that had post-fertilization effects, they would stop using that method. Lopez-del Burgo C, Lopez-de Fez CM, Osorio A, Guzmán JL, de Irala J. Spanish women’s attitudes towards post-fertilization effects of birth control methods. Eur J Obstet Gynecol Reprod Biol. 2010 Jul;151(1):56-61. doi: 10.1016/j.ejogrb.2010.03.012. Epub 2010 Apr 13. PMID: 20392555. https://pubmed.ncbi.nlm.nih.gov/20392555/

3.
Pitman says “despite Andrew’s adamant assertion that the angel Gabriel defined John the Baptist as being of full moral value from the moment of conception, Gabriel never actually said that. Gabriel was simply noting that the Word of God, the foreknowledge of God, never fails.” RESPONSE: This is both false and absurd as Gabriel is describing a physical situation wherein the nature of the unborn is defined with the exact same Greek words for born sons. Pitman assumes a false dichotomy between “moral value” of the unborn and its nature but he is unable to provide any scriptural evidence for such a dichotomy.

4.
Pitman says “Taken together, all of the translations of this passage [Exodus 21:22-23] leave the question as to the moral value of the human embryo as not clearly answered or defined.” This is false because as was explicitly stated in the video, the Masoretic, LXX, and DSS all agree. The weight of the evidence is against Pitman here. And as was noted above, Pitman is here assuming a dichotomy for which he has no evidence. Furthermore, as was noted explicitly in the video @49:13, Pitman is committing a category error by comparing unintentional vs. intentional. Despite this being addressed explicitly Pitman ignores this as well. (This is the same Pitman @54:16 who criticizes others for rejecting the weight of evidence).

5.
Arguably, one of the biggest falsehoods is when Pitman complains that Prolife Andrew is “often sarcastic and needlessly abrasive in his tone and has a habit of misrepresenting or distorting the positions of those he attacks in his YouTube videos. He’s just not even handed in how he presents and deals with the those who hold differing views. I just don’t see this as being at all Christlike or remotely helpful.” This is false because Prolife Andrew’s videos began in 2017. There have been many prolife voices within Adventism especially since the late 1980s and early 1990s. Pitman complains about Andrew’s tone but doesn’t make such accusations against those who for decades preceded Andrew because he can’t. Nic Samojluk, Doug Yowell, Teresa Beem, Dr. Martin Weber, George Gainer, George Lawson, Dr. Richard Fredericks, etc. were all well known and continue to be outspoken about the Adventist Church’s support for murder. As was mentioned in the video @34:50 Pitman also ignores the arguments of Drs. Robert George and Christopher Tollefson who are some of the most highly respected, articulate voices concerning the ethics of (embryonic) abortion. For these people Pitman can’t make accusations of “abrasive tone” so he simply continues his trend of just ignoring them. This tactic was explicitly noted @58:56 and Pitman just again vindicates the accuracy of the video.

Pitman belongs to a church that has, by his own definition, officially and publicly supported the violent murder of helpless, little children for over fifty years.


Updating the SDA Position on Abortion
Andrew Michell (AKA: ProLife Andrew) has put out a lengthy video in response to my article on abortion.

His YouTube Channel can be found here: Link
And his Facebook page here: Link
And his page on X here: Link

While I commend Andrew’s passion to protect the lives of the unborn, I find his argument that full human life begins at the moment of conception unconvicting – at least inconclusive. I mean, if the full moral value of human life truly begins at the moment of conception, as Andrew, the Catholic Church, and many Protestants believe, then all women who use various forms of birth control that block embryologic development (after fertilization) are forms of premeditated murder (to include IUDs and various birth control medications).

  • Progestin-only pills (mini-pill): These pills thicken cervical mucus, making it harder for sperm to reach the egg, and thin the lining of the uterus, making it less hospitable for implantation.
  • Combined oral contraceptives (the pill), patch, vaginal ring, and injections: These methods prevent ovulation, meaning no egg is released for fertilization, and also thicken cervical mucus and thin the uterine lining.
  • Contraceptive implant (Nexplanon): This small rod inserted under the skin releases progestin, reducing pregnancy by reducing ovulation, thickening cervical mucus, and thinning the uterine lining reducing implantation.
  • Hormonal IUD: These IUDs release progestin, which changes the cervix and uterus to prevent sperm from reaching an egg and also makes it difficult for a fertilized egg to implant.
  • Copper IUD: This IUD uses copper to prevent pregnancy by creating an environment that is unfavorable for sperm and fertilization, and also disrupts the lining of the uterus, making implantation less likely.
  • Emergency contraception: Some emergency contraceptive pills, like Plan B, can prevent implantation if taken soon after unprotected sex.

So, are women who use such birth control methods truly guilty of murder? – as Andrew’s position would indicate?

While it is true that the genetics of a person are set at conception, what about the moral worth of a person? You see, science cannot address this question. So, where can one turn to find out the answer? Well, as Christians, the Bible should be our first and primary source to search for answers to moral questions. And, I applaud Andrew for trying to do this. In support of the concept that full human life begins at the moment of conception Andrew cites various Biblical passages. Here are examples of Bible passages that Andrew finds most convincing in this regard:

    “Surely I was sinful at birth, sinful from the time my mother conceived me.” – Psalms 51:5

    “Even Elizabeth your relative is going to have a child in her old age, and she who was said to be unable to conceive is in her sixth month. For no word from God will ever fail.” – Luke 1:36-37

    “For you created my inmost being; you knit me together in my mother’s womb.” – Psalms 139:13

    “Before I formed you in the womb I knew you, before you were born I set you apart; I appointed you as a prophet to the nations.” – Jeremiah 1:5

For Andrew, these and other similar passages are conclusive evidence of the full value of humanity starting at the moment of conception. However, many honest Christians just don’t see it this way. Andrew cannot understand how anyone could honestly disagree with him after hearing out his arguments, but I for one am honestly not convinced. And, it’s not because I don’t want to know the truth as God wishes me to know it. It’s because I don’t see anywhere in these passages that Andrew cites where God makes the idea clear that the full value of humanity begins at the moment of conception.

Add to this the passage in Exodus 21:22-25 (discussed in some detail in my article above) that seems to support the conclusion that there is a spectrum as to the moral value of human life during embryological/fetal development. Certainly the writers of the LXX (3rd to 1st century B.C.) supported this conclusion hundred years before the Masoretic Text was written (7th to 10th centuries A.D.). And, while it is true that the Samaritan Pentateuch overlapped the production of the LXX, it is not true that the language of the Samaritan Pentateuch, regarding this passage in Exodus, is definitively unambiguous – certainly not unambiguous enough to discount the LXX translation of this passage. Taken together, all of the translations of this passage leave the question as to the moral value of the human embryo as not clearly answered or defined.

But what about the passages that Andrew cites? Don’t these passages clearly demonstrate God’s Design of the embryo from the very moment of conception? And, if so, is anyone at liberty to destroy or even hinder what God is forming? Well, look at the passage from Jeremiah 1:5 where God explains that he knew of the future existence of Jeremiah before he was even conceived. This passage simply speaks to the foreknowledge of God rather than to the moral value of a human embryo or a single fertilized cell. It really doesn’t answer the question as to if a deliberate ending of an an early pregnancy, such as after a few days of fertilization, is truly considered “murder” in the site of God. Also, despite Andrew’s adamant assertion that the Angel Gabriel defined John the Baptist as being of full moral value from the moment of conception, Gabriel never actually said that. Gabriel was simply noting that the Word of God, the foreknowledge of God, never fails. But what about David claiming that he was “sinful from the moment of conception”? Well, it’s hard for me to definitively argue that this is clearly more than poetic license. After all, Jesus Himself noted that unless a person consciously knows the truth, and deliberately choses to do otherwise, there is no sin (John 9:41; John 15:22; James 4:17). How then can a single cell, or a small cluster of cells that is unable to think or act, be guilty of sin? – beyond the fact that we are conceived and born in a state of moral separation from God? Again, I fail to see such arguments as conclusive support for Andrew’s position that women who use the various forms of birth control described above are guilty of murder. Not even the founders of the SDA Church said anything about full humanity being instantly realized at the moment of conception. Yes, they were opposed to abortion (Link). However, modern birth control methods had yet to be invented. Would they really be opposed to such birth control methods? We cannot know, for sure, but I doubt it. Certainly there is no clear or definitive guidance regarding this particular question from the Bible, the Spirit of Prophecy, or the Founders of the SDA Church.

And, that’s my main concern here. At what point would I be willing to accuse a woman of being a murderer? – worthy of arrest and execution for deliberately taking the life of another human being? I just do not see the clear Biblical support, or support from any other inspired authority, for making such a charge when it comes to a single cell or a tiny ball-shaped cluster of cells. Sure, once the body of the baby is formed, and certainly once the brain of the baby is functional, things become much more clear in my own mind regarding the moral value of the baby as a full human being with all of the moral God-given rights thereof. It’s just that I honestly see no solid basis for accusing a woman of murder for blocking or terminating a pregnancy very early on following conception when the pregnancy consists only of a single cell or a small cluster of cells.

What is also most interesting is that, in his review of my article, Andrew gets a bit upset with me saying that I’m the one using “inflammatory language” such as “first-degree cold-blooded murder”. Surprisingly, Andrew would evidently be fine with a “lesser charge” such as “involuntary manslaughter” (57:00) for women who use birth control that prevents embryonic implantation or who otherwise deliberately abort their babies. I’m actually really surprised by this particular argument since, if one truly views a full human life as beginning at the moment of conception, how can one argue that the deliberate termination of such a life is anything other than a deliberate pre-meditated murder? I mean, it’s almost as if Andrew doesn’t really believe what he’s saying regarding the full value of human life beginning at conception. He does discuss birth control pills or IUDs (starting around the 17-minute mark) that block the implantation of the embryo, thus aborting it, but claims that the mother’s lack of knowledge as to exactly when this happens means that she isn’t really guilty of premeditated murder. Really? It’s like arguing that deliberately putting lethal poison into apples or candy or medication at the supermarket isn’t really premeditated murder because the one doing this doesn’t know exactly when someone will actually die. That argument is clearly false on its face. And, contrary to Andrew’s claims, this has nothing at all to do with the government proving or doing anything. It has nothing to do with human governments at all. It has to do with the morality of a woman deliberately doing something that she knows will likely end pregnancy shortly after conception. If this act really is the taking of full human life, it is premeditated murder before God. There’s just no other term to use if full human life really does begin at the moment of conception.

Another relevant issue involves the use of IUDs and birth control pills to regulate hormonal issues that many women suffer. Andrew suggests that condom use would overcome such issues. However, even if condoms are always and correctly used with every act of intercourse, they have around a 3% failure rate (Link, Link) with some studies showing a failure rate of condoms of up to 16% per year (Link). In other words, even if a condom is being used by the husband every single time he has sex with his wife, at best there is still around a 3% chance of impregnating his wife within a given year. If she is also on hormonal birth control, that means that there is a ~3% chance of killing a real human being if full human life truly begins at conception. How is this a viable solution given the reality of Andrew’s position? Basically, what married couples would be left with is the Catholic concept of not having vaginal sex unless they are actually trying to get pregnant. Just because not every such effort would be successful, as Andrew points out in his video, is completely irrelevant to the required motive that would be necessary before couples could engage in sex without guilt – without the possibility of committing murder. In other worlds, no sexually active woman could ever take advantage of the benefits of hormonal birth control without the guilt of murder on her conscience – even if her husband always uses a condom (which is also less fun by the way).

Andrew also claims that I have done “nothing” to combat abortion, not even late-term abortion (i.e., an induced ending of pregnancy after the 20th week) – despite the fact that I’ve written this particular article calling late term abortion murder in no uncertain terms – and having directly prevented such an abortion when it was in my power to do so as a medical officer in the US Army (something that not even Andrew has been able to do). In fact, several church leaders have contacted me due to their favorable impression of my article on abortion, including religious liberty lawyers. Portions have even been included in religious liberty literature regarding this topic. The religious liberty lawyer for northern and central California conferences, Stephen Allred, included much of my article in the appendix of his book, “Do Justice: The Case for Biblical Social Justice” (Link). And no, he is no relation to the notorious abortion doctor Edward C. Allred, who outright murdered a great many late-term babies.

I guess Andrew feels that this doesn’t go nearly far enough. It’s just that I honestly don’t see his position as entirely accurate or conclusive or his approach to this topic as being more positive than negative. For me, Andrew’s position is without clear Biblical support regarding the claim that full humanity begins at conception and is inconsistent, as noted above, in that he argues for a lesser charge than “murder” for women who deliberately abort very early in pregnancy. He is often sarcastic and needlessly abrasive in his tone and has a habit of misrepresenting or distorting the positions of those he attacks in his YouTube videos. He’s just not even handed in how he presents and deals with the those who hold differing views. I just don’t see this as being at all Christlike or remotely helpful – at least not for me personally. It ends up harming the positive impact that one could have on an important topic, which is probably the reason that Andrew is largely ignored by the leadership of the SDA Church. Now, I understand that he believes that this issue is clearly black and white, to the point that no one his his/her right mind could honestly question his position. Perhaps, however, there are a few, like me, who just don’t have the same mental capacity to grasp what Andrew sees so clearly?

Now, I do appreciate the seriousness and righteousness of Andrew’s effort to save lives. While I may disagree with or fail to understand his arguments or his methods/approach, I do see his motives as being very good indeed! I have no problem with his sincerity or his passion to save lives. The attempt to save lives is a noble effort. However, the process, the method used, is also important. I mean, consider that Jesus, who was trying to save souls as well as lives, was much more patient and tactful in his approach – a pattern that would serve us all well to emulate as we deal with others who don’t see things in quite the same way. Yes, I know that Jesus did rarely call out exceptional cases with very harsh language. However, generally speaking, such methods should be avoided if at all possible – especially when dealing with fellow Christians who are sincere and who are actually trying to learn and to do what it right.


Liberty & Health Alliance – An Appeal for Action
God gave rational empirical “scientific” evidence to believe Noah’s message.

Many of the amazing discoveries of medical science in our day, to include the gift of vaccines and an understanding as to how the human immune system actually works, are not opposed to the Scriptures or the Spirit of Prophecy (Ellen White did not opposed the use of vaccines). They are amazing gifts from God that should not be ignored or disregarded.

In this same line, Barbara O’Neill has made numerous false and misleading claims regarding various medical therapies – particularly regarding the treatment of serious conditions like cancer. She does get some things right, but the things she gets wrong significantly overshadow the things she gets right and have significant hurt people. For example, she wraps people who have cancer (which she falsely claims is caused by fungal infections, promoted by antiobiotics and other pharmaceuticals – Link) in towels soaked in baking soda as a means to treat their cancers when such treatments do not help cancer patients in the least. (Link). Yet, she she makes a lot of money peddling these and other such worthless “therapies” to the gullible. She speaks with great confidence and assurance about things that she doesn’t remotely understand since she has no medical training. It’s not the GC or Church leadership or physicians like me making money off of “Big Pharma”. Rather, it’s the snake-oil salesmen like Peter McCullough and Barbara O’Neill, and others like them, who are making quite a lot of money selling their worthless natural remedies and conspiracy theories to their worldwide audiences. Consider that her Misty Mountain Health Retreat near Kempsey charged clients as much as $2,450 per person for a one-week stay and $8,800 for two people for two weeks. She also sells numerous books and travels around giving paid conferences and seminars. Let’s just say that she makes a very good living doing what she does (Link).

It’s not like I’m opposed to natural remedies that actually work, of course. I’m just opposed to those who promote “natural remedies” just because they’re supposedly “natural” when they don’t actually do what they’re claimed to do by those who have no understanding of medical science who make money selling their “remedies” to the gullible and the desperate. If you want to see some natural remedies promoted by someone who actually does known what he’s talking about, look up the YouTube videos put out by the well-known pulmonologist Dr. Roger Seheult.


Liberty & Health Alliance – An Appeal for Action
While recommending the vaccines, the vaccine statements clearly left the decision to vaccinate, or not, to the individual. They had nothing to do with government funding (yet another conspiracy theory). These statements were issued in an honest effort to save lives, not to make money. The “medical minds” at the BoT Symposium generally support anti-vaxxers and conspiracy theorists like Peter McCullough who are known for promoting misleading or downright false claims regarding the pandemic and the mRNA vaccines.